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. 2016 Nov 3;7(11):e2448. doi: 10.1038/cddis.2016.355

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PLD1 regulates the mobilization of phospholipids from cellular membranes to mitochondria during glucose starvation. (a and b) MDA-MB-231 cells were labeled with FL-HPC overnight, and chased in low glucose medium for 1 day (a) or 3 days (b) in the presence or absence of PLD1i (scale bar: 20 μm). Cells were permeabilized with saponin. Mitochondria were labeled by TOM22. (c) Inhibition of PLD1 led to the accumulation of FL-HPC in LAMP1-labeled autolysosomes on day 3 (scale bar: 20 μm)