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. 2016 Nov 3;7(11):e2456. doi: 10.1038/cddis.2016.287

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Serglycin induced β-catenin activation. (a) Nuclear (N) and cytosolic/membrane (C+M) fractions of β-catenin in S18 scrambled, S18 SG KD1 and S18 SG KD2 cells determined by western blot analysis. (b) Localization of β-catenin in S18 scrambled, S18 SG KD1 and S18 SG KD2 cells by confocal immunofluorescence analysis (× 400). (c) c-Myc mRNA expression (normalized to GAPDH) in the indicated cell lines. Data represent the average±S.D., n=3; *P<0.05, **P<0.01 versus DMSO-treated cells. (d) IHC staining of β-catenin and p-ERK1/2 in S18 scrambled tumor tissues and S18 SG KD2 tumor tissues (200 ×)