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Ischemia-induced damage activates DNA NHEJ repair in the lithium-medicated retina. (1) Ischemia induces DNA damage in retinal neurocytes. (2) Ischemic damage upregulates the transcription factor Nrf-1. (3) Ischemic damage downregulates the transcription factor P-CREB1. (5) P-CREB1 and Nrf-1 positively regulate ligase IV gene expression. (6) Ligase IV binds to the break sites of genomic DNA in retinal neurocytes. (7) Ligase IV promotes DNA NHEJ repair and cell survival
