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. 2016 Nov 10;7(11):e2464. doi: 10.1038/cddis.2016.368

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of CTSB/S inhibition on NF-κB activation in hepatocytes. Primary mouse hepatocytes were exposed to CA-074 (25 μM) or Z-FL (10 μM), overnight or for 4 h. (a) Nuclear protein levels were analyzed after 10 min TNF challenge. (b) A20 mRNA expression was quantified after 6 h TNF challenge. (c) A20 and IL8 mRNA expression in Hep3B cells pre-treated overnight with CA-074 (25 μM) or Z-FL (10 μM) before 6 h TNF challenge. (d) Immunoblot of CTSB in the cytosolic fraction after challenging LX2 or Hep3B cells with LPS, TNF or chloroquine (CQ, 50 μM) for 60 min. Results are given as mean±S.D., n=5; *P<0.001 versus control, and ^¶P<0.001 versus TNF