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. 2016 Nov 10;7(11):e2464. doi: 10.1038/cddis.2016.368

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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NF-κB-dependent response to LPS is controlled by cathepsins in macrophages. KCs were exposed overnight to CA-074 (75 μM) or Z-FL (7.5 μM) and (a) nuclear proteins were analyzed after LPS (50 ng/ml, 30 min) challenge, or (b) IL6 and MCP1 mRNA expression was analyzed after 6 h LPS. RAW264.7 cells were pre-treated with CA-074 (75 μM, 4 h) and (c) nuclear proteins analyzed after LPS challenge (50 ng/ml, 30 min), or (d) MCP1 and IL6 mRNA expression was analyzed after 6 h LPS. (e) Total SIRT1 activity was determined in RAW264.7 cells pre-treated with CA-074 (75 μM, overnight) and exposed to LPS (30 min). Results are given as mean±S.D., n=4; *P<0.001 versus Control, and ^¶P<0.05 versus LPS