Figure 6.

Effect of CTSB/S inhibition in an in vivo model of acute inflammation. Mice were treated with CTSB/S inhibitors (10 mg/kg) 1 h before LPS i.p. injection (1.0 mg/kg, 6 h) and (a) MCP1 and IL6 mRNA expression was determined in liver tissue, (b) ALT levels were measured in blood collected at 0, 4, 6 h, and (c) hepatic SIRT1 activity was analyzed. Results are given as a mean±S.E.M., n=6, *P<0.001 versus Control, and ^¶P<0.05 versus LPS