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. 2016 Nov 10;7(11):e2464. doi: 10.1038/cddis.2016.368

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CTSB inhibition reduces inflammatory gene expression in mice with NASH. NASH was induced by feeding mice a HFCD diet for 8 weeks, CA-074-treated mice received a daily dose (10 mg/kg) for the last week. (a) Experimental setup, (b) CTSB, SIRT1 and active Caspase-1 immunoblot of hepatic lysates, (c) transaminases in serum, (d) H&E and Sirius Red staining. Results are given as mean±S.E.M., n=6, *P<0.01 versus Control. (e) Gene array of Control, HFCD, and HFCD+CA-074 mice displaying only those genes altered in the HFCD group that significantly improved after CA-074 treatment. For complete gene array, please refer to Figure S2