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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Sci Transl Med. 2017 Jan 18;9(373):eaag2196. doi: 10.1126/scitranslmed.aag2196

Fig. 2. Schematic demonstrating the workup and monitoring of CTL infusion after an initial treatment for high-grade glioma.

Fig. 2

After enrollment in this study and upon tumor recurrence, an intracerebral Rickham catheter was installed for repetitive infusions of CTLs. Each patient underwent [18F]FHBG PET and MRI before and after CTL infusions. In addition, IL-2 was administered at regular intervals to further increase the survival and enhance the potency of the administered CTLs. CTL distribution was imaged by measuring changes in tumoral [18F]FHBG accumulation before and after infusions of cells.