Table 1.
Imaging and demographic data for all seven patients enrolled in this study.
Patient # | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Gender | M | F | F | M | F | M | M |
Age (years) | 57 | 41 | 61 | 62 | 53 | 66 | 60 |
CTL type | autologous | autologous | allogeneic | allogeneic | allogeneic | allogeneic | allogeneic |
Histology | Glioma | Glioma | Glioma | Glioma | Glioma | Glioma | Glioma |
IL13Rα2 expression | N/A | N/A | 2-3+ / 80% | 2-3+ / 80% | 2-3+ / 70% | 2+ / 60% | 2+ / 90% |
Site of primary tumor | right parietal | right parieto-occipital | splenium of corpus callosum and left parietal | right occipital | left temporal | right fronto-parietal | left frontal |
Site of recurrence | right occipital | right parieto-occipital | splenium of corpus callosum and left parietal | genu of corpus collosum and bifrontal | left temporal | right fronto-parietal | left parietal |
MRI pre-CTL | 08/03/2006 | 15/01/2009 | 23/03/2011 | 15/02/2012 | 09/05/2012 | 12/09/2012 | 06/03/2013 |
MRI post-CTL | 18/04/2006 | 25/02/2009 | 15/05/2011 | 12/03/2012 | 05/06/2012 | 08/10/2012 | 26/03/2013 |
[18F]FDG pre-CTL | 09/03/2006 | 14/01/2009 | 23/03/2011 | 15/02/2012 | 10/05/2012 | 14/09/2012 | 08/03/2013 |
[18F]FDG post-CTL | N/A | N/A | 16/05/2011 | 17/03/2012 | 06/06/2012 | 08/10/2012 | 27/03/2013 |
[18F]FHBG pre-CTL | N/A | 05/01/2009 | 21/04/2011 | 17/02/2012 | 11/05/2012 | 13/09/2012 | 07/03/2013 |
[18F]FHBG post-CTL | 17/04/2006 | 23/02/2009 | 09/05/2011 | 06/03/2012 | 01/06/2012 | 04/10/2012 | 28/03/2013 |
Lesion total activity pre-CTL | - | 10.1 | 3.5 | 2.9 | 23.1 | 4.1 | 1.8 |
Lesion total activity post-CTL | #1, 4.9; #2, 0.8 | 20.3 | 8.4 | 6.3 | 28.1 | 8.4 | 6.8 |
Non-injected foci total activity pre-CTL | - | - | - | 2.4 | - | - | 1.6 |
Non-injected foci total activity post-CTL | - | - | - | 3.2 | - | - | 2.7 |