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. 2016 Dec 22;7(12):e2523. doi: 10.1038/cddis.2016.441

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Rab8a and Rab11a are necessary for TNT formation in SCs. (a and b) Rab8a and Rab11a (green) co-localized with F-actin (red). Higher magnification images are shown in boxed areas. Scale bars, 20 μm. (c) Transfected Rab8a-RFP and Rab11a-GFP also transferred between SCs via TNTs. Scale bars, 10 μm. (d) qRT-PCR and (e) western blot analysis shown that the mRNA and protein expressions of Rab8a and Rab11a were significantly decreased by knockdown with siRNA-2. (f) Downregulation of Rab8a and Rab11a result in a decrease in the number of TNTs in SCs. *P<0.05 and **P<0.01 versus NC. Scale bars, 100 μm