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. 2016 Dec 22;7(12):e2523. doi: 10.1038/cddis.2016.441

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of Rab8a or Rab11a on BDNF secretion of SCs and axonal outgrowth. (a) BDNF co-localiazation of F-actin indicates the transfer of BDNF may via TNTs. Scale bars, 50 μm. (b) The ELISA data confirmed that BDNF secretion was reduced from SCs transfected with Rab8a or Rab11a siRNA. (c) Immunostaining with anti-Tuj1 showing that axon outgrowth was decreased in co-culture consisting of DiO labeled SCs, which had been transfected with Rab siRNA. Scale bars, 50 μm. (d) Relative length of longest neurites was analyzed with Image-Pro Plus 7.0 software. *P<0.05 and **P<0.01 versus NC