Table 1. Molecular characteristics and IC50 values of AML cell lines.
Cell line | FAB | NPM1 | FLT3 | p53 | IC50 (nM) |
---|---|---|---|---|---|
NB4 | M3 | wt | wt | Mut | 1100 |
HL-60 | M2 | wt | wt | Del | 643 |
MV4-11 | M5 | wt | ITD | wt | 116 |
OCI-AML3 | M4 | Mut A | wt | wt | 112 |
Molm-13 | M5 | wt | ITD | wt | 78 |
Abbreviations: Del, deletion; FAB, French-American-British classification; FLT3=fms-related tyrosine kinase 3; ITD, internal tandem duplication; Mut, mutant; wt, wild-type