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. 2016 Dec 8;7(12):e2519. doi: 10.1038/cddis.2016.413

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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YopM E3 ligase activity is important for bacterial virulence. (a) Groups of 15 male and female mice were challenged by intravenous injection of 100 CFU WT, ΔYopM, ΔYopM/YopM, or ΔYopM/YopM C68A Y. pestis and monitored over 10 days for development of disease. Data shown were collected in two independent experiments, n=15 mice per group in each experiment. (b) Lung, liver, or spleen from mice infected with WT, ΔYopM, ΔYopM/YopM, or ΔYopM/YopM C68A strains for 3 days were subjected to histopathological analysis by staining with HE. Each micrograph shows an example of the pathology caused by each strain. Data shown are representative from two independent experiments (n=5 mice per strain). (c) Mean severity scores for histopathology of lungs, liver, and spleen from mice infected with different background of bacteria strains on day 3