. 2016 Dec 8;7(12):e2515. doi: 10.1038/cddis.2016.408

Table 1. Link between Pathways related to inflammation and non-canonical Notch pathways: involved molecular mechanisms.

Inflammation-linked pathway	Molecular mechanism	Effect	Model	References
NFκB Signaling	Induction of Jagged 1 expression in non-cancer stem cells	Stimulation of Notch signaling in cancer stem cells	Basal-like breast cancer cell lines	²¹
	Induction of PI3K/Akt pathway	Activation of Notch1, tumor growth	Human melanoma samples and cell lines	²³
Tissue Hypoxia	Stabilization of HIF-1a	Activation of Notch, tumor growth	Human melanoma samples and cell lines	²³
	Stabilization of Hif-1a	Augmented Notch1 signaling, altered expression of cell cycle regulatory proteins, accelerated cell proliferation	T-cell acute lymphoblastic leukemia cells	²⁴
	Induction of Notch pathway, up-regulation of Notch ligand expression	Induced EMT, E-Cadherin down-regulation, expression of Snail1	Cell lines of cervical, colon, glioma and ovarian cancer; breast cancer	^{26, 27}
	Induction of 66-kDA isoform of the SHC gene (p66Shc)	Induction of Notch3 signaling, self-renewal (induction of Jagged1) and hypoxia survival	Mammospheres	²⁵
Epithelial to mesenchymal transition (EMT)	Transforming growth factor-beta (TGF-b) induction	Expression of Hey1 and Jagged1	Epithelial cells from mammary gland, kidney tubules and epidermis	²⁸
WNT	β-catenin/TCF-mediated transcriptional activation of Jagged1	Activated Notch1 and Notch2 in tumors containing nuclear β-catenin	Colorectal cancer cells, human tumors from FAP	³⁰