Table 2. Role of interaction between MMP9 and Notch pathway in colon carcinogenesis.

MMP9 function	Molecular mechanism	Effect on Notch pathway	Model	References
Protective role against CAC	Activation of p21WAF1/Cip1, suppression of b-catenin	Increased Notch1 activation	MMP9-/- and WT mice; AOM/DSS mouse model	66
Enhanced susceptibility to mucosal inflammation	Claudin-1 induced activation	Activation of Notch signaling, inhibition of differentiation of intestinal epithelial cells into goblet cells, decrease of Muc-2 positive cells	Villin-claudin1 transgenic mouse model	67
Oncogenic role in CRC	Inflammation-driven activation	Overexpression of NICD and Jagged1; induction of Notch-regulated ankyrin repeat protein 1	In vitro model of interaction between macrophages and CRC cells	29