Figure 1.
Gain-of-function of cul-4 can rescue reduced eye mutant phenotype. (a and b) Wild-type (a) eye-antennal imaginal disc and (b) adult eye. The eye disc is stained for a membrane specific marker, Dlg (green); dorsal eye fate marker, Mirr (blue); and pan-neural marker, Elav (red). The white dotted line marks the boundary of eye field. (c and d) L2 mutant exhibits reduced eye phenotype in (c) eye imaginal disc and (d) adult eye. (e and f) Misexpression of cul-4 in the L2 mutant eye background (L2; ey> cul-4) results in a significant rescue to a near wild-type eye as seen in (e) the eye disc and (f) the adult eye