Figure 10.

cul-4 promotes cell survival by regulating wg and JNk signaling in the developing eye. (a–c) Wg expression in (a) wild-type, (b) cul-4^−/−; ey> jun^aspv7; and (c) cul-4^−/−; ey>puc eye imaginal disc. Note that Wg levels are upregulated when JNK signaling is activated, whereas Wg levels are not much affected when JNK signaling is downregulated. p-JNK expression in (a) wild-type, (b) cul-4^−/−; ey> wg; and (c) cul-4^−/−; ey>dTCF^DN eye imaginal disc. Note that pJNK levels are not affected. (g) During eye development cul-4 is involved in (i) downregulating Wg signaling and (ii) inhibiting JNK signaling to promote cell survival. Activated JNK signaling can trigger Wg induction