Figure 8.

Aberrant Wg signaling triggers cell death in cul-4 loss-of-function background. Eye imaginal discs showing TUNEL (blue) labeling in (a and a') ey>wg, (b and b') cul-4^−/−; ey>wg (c and c') ey>sgg^S9A, (d and d') cul-4^−/−; ey>sgg^S9A, (e and e') ey>dTCF^DN and (f and f') cul-4^−/−; ey> dTCF^DN. (g) Graph shows quantification of the number of dying cells in the wild-type, cul-4 loss-of-function and genotypes shown in (a–f). Note that in cul-4 loss-of-function background cell death is enhanced when Wg is activated. Conversely, cell death is suppressed to near wild-type when Wg signaling is blocked in cul-4 loss-of-function background