Figure 9.

Aberrant JNK signaling triggers cell death in cul-4 loss-of-function background. Panels show TUNEL (blue) staining marking the dying cells nuclei in eye discs from (a and a') ey>jun^aspv7, (c and c') ey>puc, (e and e') ey>bsk^DN, (b and b') cul4^−/−; ey>jun^aspv7, (d and d') cul4^−/−; ey>puc or (f and f') cul4^−/−; ey> bsk^DN. (g) Graph shows a comparison of the number of dying cells in wild-type, cul-4 loss-of-function and the genotypes shown in a–f. Note that rate of cell death is enhanced when JNK signaling is activated whereas the rate of cell death is suppressed when JNK signaling is blocked in cul-4 loss-of-function background