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. 2016 Dec 1;7(12):e2494. doi: 10.1038/cddis.2016.393

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CD44 correlates with low pMAPK expression and is a putative biomarker of sensitivity to cAMP-induced apoptosis in GBM. (a) Comparison of pMAPK expression in GBM cell lines (n=3). (b) Correlation of pMAPK expression and apoptosis upon treatment with Fsk–IBMX (n=6). (c) Immunohistochemical analysis of a representative GBM specimen showing inverse correlation between pMAPK and CD44. (d) FACS analysis of GBM cell lines showing CD44 expression in all sensitive cells and no expression in resistant cells (n=3). (e) Western blot showing expression of CD44 in the GBM cell lines. Error bars are S.E.M.