Table 1.
Causes of death and two-year mortality rates among all DTP participants 2001 – 2012 (irrespective of the year in which they started ART)
| Time Period | 2001–2002 | 2003–2004 | 2005–2006 | 2007–2008 | 2009–2010 | 2011–2012 | Total | p-value† | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N=4002 | N=4268 | N=4577 | N=5064 | N=5669 | N=6244 | N=8185 | |||||||||
| n (%) | MR | n (%) | MR | n (%) | MR | n (%) | MR | n (%) | MR | n (%) | MR | n (%) | MR | ||
| Any death | 257 (6.42) | 3.88 | 294 (6.89) | 4.16 | 318 (6.95) | 4.24 | 240 (4.74) | 2.94 | 228 (4.02) | 2.46 | 224 (3.59) | 2.15 | 1561 (19.07) | 4.84 | 0.02 |
| HIV related | 155 (3.87) | 2.34 | 175 (4.10) | 2.47 | 208 (4.54) | 2.77 | 136 (2.69) | 1.67 | 93 (1.64) | 1.00 | 58 (0.93) | 0.56 | 825 (10.08) | 2.56 | 0.02 |
| Non-HIV related | 102 (2.55) | 1.54 | 119 (2.79) | 1.68 | 110 (2.41) | 1.47 | 104 (2.05) | 1.28 | 135 (2.38) | 1.46 | 166 (2.66) | 1.60 | 736 (0.99) | 2.28 | 0.69 |
| Specific Causes of Death (non-HIV) | |||||||||||||||
| Other infectious and parasitic disease | 4 (0.1) | 0.06 | 9 (0.21) | 0.13 | 5 (0.11) | 0.07 | 6 (0.12) | 0.07 | 3 (0.05) | 0.03 | 3 (0.05) | 0.03 | 30 (0.37) | 0.09 | 0.16 |
| Cancer (non-AIDS) | 12 (0.3) | 0.18 | 20 (0.47) | 0.28 | 18 (0.39) | 0.24 | 18 (0.36) | 0.22 | 36 (0.64) | 0.39 | 21 (0.34) | 0.20 | 125 (1.53) | 0.39 | 0.58 |
| Cardiovascular disease | 16 (0.4) | 0.24 | 16 (0.37) | 0.23 | 15 (0.33) | 0.20 | 19 (0.38) | 0.23 | 8 (0.14) | 0.09 | 5 (0.08) | 0.05 | 79 (0.97) | 0.25 | 0.03 |
| Chronic respiratory diseases | 3 (0.07) | 0.05 | 1 (0.02) | 0.01 | 3 (0.07) | 0.04 | 5 (0.1) | 0.06 | 5 (0.09) | 0.05 | 4 (0.06) | 0.04 | 21 (0.26) | 0.07 | 0.50 |
| Chronic Liver Disease | 13 (0.32) | 0.20 | 12 (0.28) | 0.17 | 10 (0.22) | 0.13 | 7 (0.14) | 0.09 | 4 (0.07) | 0.04 | 9 (0.14) | 0.09 | 55 (0.67) | 0.17 | 0.01 |
| Unintentional Injuries | 6 (0.15) | 0.09 | 9 (0.21) | 0.13 | 2 (0.04) | 0.03 | 5 (0.1) | 0.06 | 9 (0.16) | 0.10 | 0 (0) | 0 | 31 (0.38) | 0.10 | 0.23 |
| Suicide | 31 (0.77) | 0.47 | 25 (0.59) | 0.35 | 21 (0.46) | 0.28 | 25 (0.49) | 0.31 | 13 (0.23) | 0.14 | 0 (0) | 0 | 115 (1.41) | 0.36 | 0.003 |
| Other causes of death | 17 (0.42) | 0.26 | 27 (0.63) | 0.38 | 36 (0.79) | 0.48 | 19 (0.38) | 0.23 | 57 (1.01) | 0.61 | 124 (1.99) | 1.19 | 280 (3.42) | 0.87 | 0.07 |
Note: For each time period, for calculation of proportion (%), DTP participants were required to start ARV at least 3 months before the end of that period (e.g. 2001–2002, require participants start ARV ≤ Sep 30, 2002; a death is counted if it happens between Jan 01 2001 and Dec 31 2002); for calculation of mortality ratio (MR), no restriction was applied.
†
p-values were calculated for trend analysis based on the MR of every two year period