Table 2.
Comparison of Patient Demographics Among Individuals Initiating ART in each two-year period N=4412 people started ARV 2001–2012 and have >=12 months follow up
| Variable | Year of Initiation of ART | p-value | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| 2001–2002 (N=555) |
2003–2004 (N=575) |
2005–2006 (N=659) |
2007–2008 (N=875) |
2009–2010 (N=901) |
2011–2012 (N=847) |
||
|
| |||||||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||
|
| |||||||
| Sex | 0.27 | ||||||
| Female | 130 (23) | 126 (22) | 143 (22) | 172 (20) | 180 (20) | 158 (19) | |
|
| |||||||
| Aboriginal ancestry | <0.001 | ||||||
| No | 269 (48) | 287 (50) | 243 (37) | 293 (33) | 233 (26) | 167 (20) | |
| Yes | 93 (17) | 69 (12) | 83 (13) | 108 (12) | 101 (11) | 96 (11) | |
| Unknown | 193 (35) | 219 (38) | 333 (51) | 474 (54) | 567 (63) | 584 (69) | |
|
| |||||||
| Age at HAART Initiation, median (IQR)† | 39 (33–46) | 41 (35–48) | 42 (36–49) | 42 (35–49) | 42 (34–49) | 41 (33–49) | <0.001 |
|
| |||||||
| AIDS defining illness before ART | <0.001 | ||||||
| Yes | 91 (16) | 114 (20) | 111 (17) | 109 (12) | 105 (12) | 67 (8) | |
|
| |||||||
| Baseline CD4 | <0.001 | ||||||
| < 50 | 92 (17) | 94 (17) | 95 (15) | 82 (10) | 76 (8) | 51 (6) | |
| 50–199 | 236 (43) | 263 (46) | 278 (43) | 289 (34) | 190 (21) | 122 (15) | |
| 200–349 | 142 (26) | 153 (27) | 196 (30) | 340 (40) | 330 (37) | 201 (24) | |
| >= 350 | 82 (15) | 59 (10) | 80 (12) | 147 (17) | 300 (33) | 467 (56) | |
|
| |||||||
| Baseline CD4, median (IQR)† | 170 (80–275) | 160 (80–230) | 180 (100–250) | 220 (140–290) | 280 (170–390) | 370 (230–530) | <0.001 |
|
| |||||||
| Baseline VL (c/mL) | <0.001 | ||||||
| <100000 | 252 (46) | 269 (48) | 324 (51) | 492 (57) | 617 (69) | 585 (70) | |
|
| |||||||
| HCV | <0.001 | ||||||
| Always negative | 245 (44) | 287 (50) | 355 (54) | 485 (55) | 543 (60) | 542 (64) | |
| Ever positive | 256 (46) | 257 (45) | 262 (40) | 332 (38) | 296 (33) | 217 (26) | |
| Unknown | 54 (10) | 31 (5) | 42 (6) | 58 (7) | 62 (7) | 88 (10) | |
|
| |||||||
| HIV transmission risk group | <0.001 | ||||||
| Unknown or No information | 160 (29) | 166 (29) | 227 (34) | 293 (33) | 395 (44) | 441 (52) | |
| IDU | 211(38) | 213 (37) | 229 (35) | 276 (32) | 266 (30) | 195 (23) | |
| MSM | 128 (23) | 107 (19) | 112 (17) | 177 (20) | 141 (16) | 144 (17) | |
| Heterosexual | 33 (6) | 54 (9) | 52 (8) | 82 (9) | 66 (7) | 53 (6) | |
| IDU and MSM | 23 (4) | 35 (6) | 39 (6) | 47 (5) | 33 (4) | 14 (2) | |
|
| |||||||
| Virologic suppression (first year on ART) | <0.001 | ||||||
| Yes | 403 (73) | 450 (78) | 554 (84) | 767 (88) | 823 (91) | 765 (90) | |
|
| |||||||
| AIDS defining illness after HAART | <0.001 | ||||||
| Yes | 62 (11) | 53 (9) | 46 (7) | 49 (6) | 21 (2) | 14 (2) | |
|
| |||||||
| Adherence to therapy (first year of ART) | <0.001 | ||||||
| >= 95% | 303 (55) | 355 (62) | 454 (69) | 586 (67) | 634 (70) | 580 (68) | |
|
| |||||||
| Third drug class of baseline therapy | <0.001 | ||||||
| Unboosted PI | 62 (12) | 20 (4) | 41 (6) | 18 (2) | 2 (0) | 0 (0) | |
| Boosted PI | 157 (31) | 275 (49) | 401 (61) | 495 (57) | 420 (47) | 398 (47) | |
| NNRTI | 275 (54) | 254 (45) | 213 (32) | 345 (40) | 464 (51) | 399 (47) | |
| Other | 19 (4) | 12 (2) | 1 (0) | 14 (2) | 15 (2) | 50 (6) | |
|
| |||||||
| Physician experience, median (IQR)† | 129 (28–362) | 86 (18–275) | 104 (37–255) | 124 (33–312) | 159 (37–331) | 157 (40–330) | <0.001 |
|
| |||||||
| Deceased | <0.001 | ||||||
| All-cause death | 132 (24) | 106 (18) | 83 (13) | 77 (9) | 40 (4) | 10 (1) | |
|
| |||||||
| Underlying cause of death | NA | ||||||
| HIV-related disease | 67 (12) | 54 (9) | 30 (5) | 21 (2) | 7 (1) | 3 (0) | |
| Other infectious and/or parasitic diseases | 5 (1) | 0 (0) | 3 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Cancer (non-AIDS) | 10 (2) | 8 (1) | 8 (1) | 10 (1) | 3 (0) | 0 (0) | |
| Cardiovascular Disease | 7 (1) | 7 (1) | 5 (1) | 3 (0) | 2 (0) | 1 (0) | |
| Chronic Respiratory Diseases | 1 (0) | 2 (0) | 2 (0) | 1 (0) | 1 (0) | 0 (0) | |
| Chronic Liver Disease | 1 (0) | 3(1) | 6 (1) | 1 (0) | 2 (0) | 0 (0) | |
| Unintentional Injuries | 0 (0) | 1 (0) | 3 (0) | 3 (0) | 0 (0) | 0 (0) | |
| Suicides | 11 (2) | 3 (1) | 4 (1) | 1 (0) | 0 (0) | 0 (0) | |
| Other Causes of Death | 30 (5) | 28 (5) | 22 (3) | 37 (4) | 25 (3) | 6 (1) | |
†
denotes a continuous variable; data is expressed as median and 25th–75th percentile according.
Physician experience = the number of patients for whom the individuals’ treating physician has previously prescribed ART.