Table 1.
Physicochemical characterization of HSN, PTX-SN, and PTX-HSN
| Formulation | Mean diameter (nm) | Polydispersity index | Zeta potential (mV) | Encapsulation efficiency (%)a | Drug loading efficiency (%)b | Drug content (mg/mL)c |
|---|---|---|---|---|---|---|
| HSN | 79.1±3.99 | 0.18±0.02 | −37.3±0.46 | – | – | – |
| PTX-SN | 57.3±8.43 | 0.22±0.04 | 34.5±0.54 | 99.8±0.08 | 3.75±0.02 | 3.00±0.04 |
| PTX-HSN | 80.3±4.81 | 0.20±0.03 | −36.9±0.53 | 100.1±0.06 | 3.69±0.01 | 3.00±0.03 |
Notes: Data are presented as mean ± SD (n=3).
a
Encapsulation efficiency (%) = (amount of PTX encapsulated in SN or HSN/amount of feeding PTX) ×100%;
b
drug loading efficiency (%) = (amount of PTX in SN or HSN/amount of feeding material and PTX) ×100%;
c
drug content (mg/mL) = (amount of PTX in SN or HSN/amount of feeding material and PTX in the 10 mL vial).
Abbreviations: HSN, hyaluronan solid nanoemulsions; PTX-SN, paclitaxel-loaded solid nanoemulsions; PTX-HSN, paclitaxel-loaded hyaluronan solid nanoemulsions.