Fig 5. Known pioneer TF subfamilies strongly enrich in predicted chromatin accessibility regulators.

Shown in grey is a scaled cumulative distribution plot for subfamily level CAR ranks of subfamilies not annotated as pioneers in Iwafuchi-Doi et al. [3]. In black, we see the cumulative number of pioneer subfamilies that reached at least a given CAR rank. Six out of eight subfamilies show a low CAR rank, which is more than three times as many as one would expect on average when sampling from non-pioneer subfamilies.