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. 2017 Jan 24;13(1):e1005311. doi: 10.1371/journal.pcbi.1005311

Fig 6. Strong associations between GR-like receptor motif and glucocorticoid response genes.

Fig 6

a) Association results for motif accessibility of the TF NR3C1, which belongs to the GR-like receptor subfamily, and mRNA expression across all genes. -Log10 transformed p-values are shown in a QQ-plot. NR3C1 motif accessibility shows strong association with mRNA expression of three glucocorticoid response genes (orange), but only weak association with expression of NR3C1 and other GR-like receptor TFs (green). In this example, motif accessibility is strongly associated with downstream gene expression, but only weakly with expression of the TF itself. b) The network shows functional relationships among the GR-like receptor TFs (green) and the three most strongly associated genes (orange), which are all glucocorticoid response genes. The strength of links shows confidence in functional relationship given in the STRING database. We see numerous links between the downstream glucocorticoid response genes and the GR-like receptor TFs in the STRING database, confirming their functional relatedness, where NR3C1 has the most links to associated genes.