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. 2017 Jan 24;12(1):e0169882. doi: 10.1371/journal.pone.0169882

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© 2017 Asiedu et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Representative Na⁺ current traces in TG neurons in the presence of A769662. Currents were elicited in TG neurons with a current step protocol initiated from -80 mV to 0 mV for 25 msec from a holding potential of -80 mV. (B) Acute application of A769662 reduced the Na⁺ current amplitude in TG neurons (n = 6, **** p < 0.0001). C) Data generated was fitted to a hill equation to plot the dose response curve for percent current amplitude block by A769662. A769662 inhibited Na⁺ current amplitude with an IC₅₀ of 10 μM. D) Peak current vs time plot of the effect of A769662 on Na⁺ current amplitude. Arrows correspond to A769662 (blue) and washout (red) in A) and B).