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. 2017 Jan 24;12(1):e0170599. doi: 10.1371/journal.pone.0170599

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© 2017 Wang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — The left ear of ICR mice was injected with live and heat-killed P. acnes. Right ear received an equal amount of PBS serving as a control. Ce6 (1, 25 and 50 μg/ml in PBS) was epicutaneously applied on the left ear. Ce6-mediated PDT markedly decreased the expression of iNOS, NO and pro-inflammatory cytokine IL-1β induced by live and heat-killed P. acnes. Results are expressed as mean ± SEM. *P<0.05 compared with the non-stimulated control group. ^#P<0.05 compared with P. acnes stimulated mice only.