Fig 5. Bifurcation analysis of the connection weights.

The relationship between the six connection weights can be examined by using bifurcation analysis, which allows us to co-vary any two parameters at a time and trace out the region in parameter space where the bifurcation leading to oscillatory activity occurs. In this way, we can split the parameter space into oscillatory (shaded) and non-oscillatory regions and therefore make predictions about the network structure in the pathological state. Furthermore, we examined the frequency of the oscillations throughout these shaded regions and found that the frequency of oscillations does not remain constant. In fact, as parameters varied from the default values (black circle), the frequency increased (solid line) or decreased (dashed line) as shown in the plots. The frequency of oscillations we observed within these regions however, was between 2 Hz and 8 Hz.