Table 1. Experimental data used for model calibration.

The table summarizes the experimental perturbations, time scales and measured quantities for the different datasets used.

mouse strain	experimental perturbation	Ref.	Fig.	output	time scale
C57BL/6	LPS injection	new data S1 Dataset	S1 Fig	serum iron, liver hepcidin mRNA, liver BMP6 mRNA, serum IL6, liver pSTAT, liver pSMAD, spleen Fpn mRNA, liver Fpn mRNA, liver Fpn protein	72 hours
C57BL/6	LPS injection	new data S2 Dataset	Fig 3	serum iron, liver iron, spleen iron, duodenum iron, RBC iron, liver hepcidin mRNA, liver BMP6 mRNA, liver Fpn mRNA, liver pSTAT, liver pSMAD, liver Fpn protein, spleen Fpn protein	48 hours
C57BL/6	high iron diet	new data S2 Dataset	Fig 6	serum iron, liver iron, spleen iron, duodenum iron, RBC iron, liver hepcidin mRNA, liver BMP6 mRNA, liver Fpn mRNA, liver pSTAT, liver pSMAD, liver Fpn protein, spleen Fpn protein	4 weeks
C57BL/6	reduced/increased dietary iron	[41] and S3 Dataset	S2 Fig	serum iron, liver iron, spleen iron, liver hepcidin mRNA, liver BMP6 mRNA	9 weeks
C57BL/6	radioactive iron injection	[40]	S3 Fig	tracer uptake in serum, liver, bones, duodenum, spleen, RBC, other organs	28 days
wt and Hep -/- C57BL/6	LPS injection/hepcidin knockout	[38]	S4 Fig	serum iron	6 hours
Hep -/- C57BL/6	hepcidin knockout	[42]	S4 Fig	liver iron	8 months