Table 2. Experimental data used for model validation.

The table summarizes the experimental perturbations, time scales and measured quantities for the different datasets used.

mouse strain	experimental perturbation	Ref.	Fig.	output	time scale
C57BL/6	LPS injection after four weeks of high iron diet	new data	Fig 3	serum iron, liver iron, spleen iron, duodenum iron, RBC iron, liver hepcidin mRNA, liver BMP6 mRNA, liver Fpn mRNA, liver pSTAT, liver pSMAD, liver Fpn protein, spleen Fpn protein	48 hours
Slc40a1C326S	hepcidin-resistant Fpn knockin	[37]	Fig 4A	serum, liver, spleen iron	8 weeks
Smad4Co/Co;Alb-Cre	liver-specific SMAD4 knockout	[53]	Fig 4B	serum, liver, spleen iron and hepcidin	2 months