Table 2. Screen of tetracycline derivatives at 50 mg/kg.

The screen of seven tetracycline derivatives at 50 mg/kg showed differential effects on 4 h ethanol consumption, 20 h water consumption, and body weight change across 4 days on drug. The percentage of control for significant differences is given in parentheses.

Derivative	Measurement	Males	Females
Tetracycline	Ethanol Consumption	NS	NS
“	Water Consumption	NS	NS
“	Body Weight Change	NS	NS
Oxytetracycline	Ethanol Consumption	NS	NS
“	Water Consumption	NS	NS
“	Body Weight Change	NS	NS
Chlorotetracycline	Ethanol Consumption	NS	p=0.0117 (76.6%)
“	Water Consumption	NS	p=0.0011 (75.0%)
“	Body Weight Change	NS	p=0.0155 (95.2%)
Demeclocycline†	Ethanol Consumption	p<0.0001 (26.0%)	p<0.0001 (36.1%)
“	Water Consumption	p=0.0001 (44.9%)	p=0.0005 (41.1%)
“	Body Weight Change	p=0.0001 (80.8%)	p=0.0008 (85.1%)
Doxycycline#	Ethanol Consumption	NS	NS
“	Water Consumption	NS	NS
“	Body Weight Change	NS	NS
Minocycline# Data from (Agrawal et al., 2014)	Ethanol Consumption	p<0.05 (65.0%)	p<0.0001 (63.0%)
“	Water Consumption	p<0.05 (82.0%)	NS
“	Body Weight Change	ND	ND
Tigecycline#	Ethanol Consumption	p=0.002 (46.5%)	p<0.0015 (80.0%)
“	Water Consumption	p=0.0017 (123.1%)	NS
“	Body Weight Change	ND	ND

NS = p > 0.05; ND = no data collected from Agrawal et al, 2014

^†2 of 5 males succumbed within 3 days of termination of the experiment.

^#semi-synthetic drug. Data are from n = 5 mice per group.