Table 3. Blood ethanol concentrations immediately following DID drinking on day 4 are generally reduced by treatment at 80 mg/kg i.p. with the three effective semi-synthetic tetracyclines.

Average BEC and SEM (N = 6-10 / group) are shown for each individual drug, along with the p-value and calculated Cohen's d effect size of each treatment compared to the saline controls.

Treatment	Sex	BEC	SEM	p-value	Cohen's d
Saline	F	0.89	0.22
Doxycycline	F	0.39	0.16	0.07	1.05
Minocycline	F	0.19	0.20	*0.03	1.33
Tigecycline	F	0.48	0.27	0.23	0.67
Saline	M	1.13	0.25
Doxycycline	M	0.74	0.17	0.19	0.74
Minocycline	M	0.58	0.21	0.10	1.02
Tigecycline	M	0.53	0.28	0.11	0.92