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Algorithm for the management of OIC.
Notes: Tradenames of specific products are trademarks or registered trademarks of their owners. aBFI should be evaluated after first-line interventions.
Abbreviations: CHF, congestive heart failure; FDA, Food and Drug Administration; OIC, opioid-induced constipation; OTC, over-the-counter; PAMORAs, peripherally acting μ-opioid receptor antagonists; BF, bowel function index.
