Table 2.
Intra- and postoperative characteristics of the patients studied as furosemide and placebo groups
| Variable | Furosemide group (n=41) | Placebo group (n=40) |
Total (N=81) |
P-value | |
|---|---|---|---|---|---|
| Aortic cross clamping (yes/no) | 28/13 | 29/11 | 57/24 | 0.432 | |
| Aortic crass clamp duration (minutes) | 76.39±40.51 | 61.31±29.98 | 68.72±30.04 | 0.115 | |
| Surgical duration (minutes) | 336.59±64.32 | 326.26±75.40 | 331.48±69.77 | 0.508 | |
| CPB duration (minutes) | 111.59±40.48 | 100.08±37.95 | 105.90±39.43 | 0.191 | |
| Inotropic usage during surgery (>60 minutes) (yes/no) |
19/22 | 19/21 | 33/43 | 0.917 | |
| Mannitol usage during surgery (yes/no) | 33/8 | 26/14 | 59/22 | 0.094 | |
| PRBC usage during surgery (yes/no) | 26/15 | 24/16 | 50/31 | 0.752 | |
| FFP usage during surgery (yes/no) | 29/12 | 32/8 | 61/20 | 0.333 | |
| Inotropic usage in ICU (>60 minutes) (yes/no) | 22/19 | 18/22 | 40/41 | 0.436 | |
| PRBC usage in ICU (yes/no) | 30/11 | 29/11 | 59/22 | 0.946 | |
| FFP usage in ICU (yes/no) | 19/22 | 21/19 | 40/41 | 0.579 | |
| Ventilatory support (hours) | 15.73±13.54 | 17.79±24.36 | 16.75±19.55 | 0.639 | |
| ICU stay time (day) | 3.76±1.52 | 3.95±2.01 | 3.85±1.78 | 0.626 | |
| Postoperative complication (yes/no) | 4/37 | 2/38 | 6/75 | 0.350 | |
| Urinary output (mL/kg/h) | Prepump period | 2.94±2.01 | 2.62±1.73 | 2.78±1.87 | 0.448 |
| On-pump period | 11.39±5.08 | 9.42±5.26 | 10.42±5.23 | 0.090 | |
| Postpump period | 7.92±3.76 | 7.96±4.86 | 7.94±4.30 | 0.965 | |
| Intraoperative period | 6.83±2.48 | 5.95±2.85 | 6.39±2.69 | 0.145 | |
| First 24 hours in ICU | 2.25±0.66 | 1.89±0.59 | 2.07±0.65 | 0.012 | |
| Creatinine (mg/dL) | Preoperative | 1.15±0.23 | 1.11±0.21 | 1.13±0.22 | 0.380 |
| Second ICU day | 1.05±0.31 | 1.28±0.41 | 1.16±0.38 | 0.005 | |
| Fifth ICU day | 1.05±0.25 | 1.24±0.40 | 1.14±0.34 | 0.014 | |
| BUN (mg/dL) | Preoperative | 18.93±5.6 | 19.98±6.1 | 19.44±5.85 | 0.424 |
| Second ICU day | 15.41±5.59 | 16.02±6.49 | 15.72±6.02 | 0.651 | |
| Fifth ICU day | 15.15±5.84 | 16.25±5.68 | 15.69±5.75 | 0.391 | |
| eGFR (mL/min/1.73m2) | Preoperative | 71.65±17.58 | 73.88±22.59 | 72.75±20.11 | 0.622 |
| Second ICU day | 83.97±26.88 | 69.43±23.11 | 76.49±25.98 | 0.011 | |
| Fifth ICU day | 81.11±24.61 | 65.99±20.33 | 73.65±23.71 | 0.004 | |
| AKI (yes/no) | 11/30 | 12/28 | 23/58 | 0.472 | |
| ARF (yes/no) | 1/40 | 6/34 | 7/73 | 0.044 | |
Note: Values are presented as mean ± standard deviation.
Abbreviations: CPB, cardiopulmonary bypass; PRBC, packed red blood cells; FFP, fresh frozen plasma; AKI, acute kidney injury; ARF, acute renal failure; ICU, intensive care unit; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen.