Fig. 1.

Cytotoxicity of Seneca Valley Virus-001 (SVV-001) in selected tumor cell lines and normal cells (described in Supplementary Table 1, available online). Cytotoxicity assays were performed as described in the text. Effective concentration 50 (EC₅₀; number of viral particles per cell required to produce 50% cell death) was determined. Log of the inverse EC₅₀ value is plotted for the cell lines listed. A) Small-cell lung cancer (SCLC), non–small-cell lung cancer (NSCLC), pediatric neuroendocrine, and endocrine (adrenal gland and pancreas) cell types. B) Other adult tumor cell types. C) Embryonic cell lines (fetal) and adult normal primary cells (PHH, primary human hepatocytes; HAEC, human aortic endothelial cells; HAoSMC, human aortic smooth muscle cells; HCAEC, human coronary artery endothelial cells; HCASMC, human coronary artery smooth muscle cells; HRCE, human renal cortical epithelial cells; HRE, human renal epithelial cells; HPASMC, human pulmonary artery smooth muscle cells; NHA, normal human astrocytes; HUVEC, human umbilical vein endothelial cells; HMVEC, human microvascular endothelial cells (skin); PBMCs, peripheral blood mononuclear cells). Means from one experiment performed in duplicate are shown.