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. Author manuscript; available in PMC: 2017 Jan 24.
Published in final edited form as: J Natl Cancer Inst. 2007 Oct 30;99(21):1623–1633. doi: 10.1093/jnci/djm198

Fig. 5.

Fig. 5

Eradication of large neuroendocrine SCLC H446 xenografts. A single injection of saline vehicle (n = 3) or Seneca Valley Virus-001 (SVV-001) at 1013 virus particles per kg (n = 10) was given to athymic mice bearing large H446 tumors (592–1996 mm3) on study day 1 (denoted by ↑). A) Mean tumor volumes and 95% confidence intervals are plotted as a function of time. B) Tumors on the flanks of mice before treatment. C) Tumors on the flanks of mice 57 days after treatment. Complete tumor regression was observed in all 10 mice treated with SVV-001 but in none of three mice treated with saline (P = .004; twosided, calculated using Fisher’s exact test).