Table 1.
Characteristics of Chronic Renal Insufficiency Cohort participants without chronic heart failure by quartile of N-terminal pro b-type natriuretic peptide (NT-proBNP)*
| Quartile | I (N=808) |
II (N=809) |
III (N=807) |
IV (N=808) |
P Value |
|---|---|---|---|---|---|
| NT-proBNP Cut Points | 2.5–55.4 | 55.5–126.6 | 126.9–303.6 | 303.7–33742.0 | <0.001 |
|
| |||||
| Age (years) | 54 (12) | 58 (11) | 60 (11) | 62 (10) | <0.001 |
| Female | 35% | 48% | 52% | 47% | <0.001 |
| Non-Hispanic White | 43% | 44% | 47% | 39% | <0.001 |
| Non-Hispanic Black | 46% | 41% | 36% | 36% | <0.001 |
| Hispanic | 7% | 10% | 13% | 21% | <0.001 |
| Other | 4% | 5% | 4% | 3% | <0.001 |
| Diabetes mellitus | 33% | 41% | 49% | 60% | <0.001 |
| Hypertension | 79% | 87% | 90% | 96% | <0.001 |
| High Cholesterol** | 82% | 86% | 85% | 89% | <0.01 |
| Current Smoker | 10% | 9% | 15% | 18% | <0.001 |
| Alcohol intake (DHQ,g) | 6.0 (12.4) | 7.0 (19.7) | 6.4 (31.4) | 6.4 (24.1) | <0.001 |
| Cardiovascular Disease | 14% | 20% | 29% | 47% | <0.001 |
| Peripheral Vascular Disease | 3% | 3% | 6% | 13% | <0.001 |
| Body Mass Index (kg/m2) | 32.0 (7.4) | 32.0 (7.5) | 32.0 (8.4) | 31.8 (8.1) | 0.86 |
| Systolic Blood Pressure (mmHg) | 128 (18) | 131 (18) | 134 (21) | 140 (22) | <0.001 |
| Diastolic Blood Pressure (mmHg) | 75 (12) | 76 (11) | 75 (13) | 74 (13) | 0.07 |
| eGFR CysC (mL/min/1.73m2) | 63.5 (20.5) | 52.9 (18.1) | 46.4 (16.6) | 38.7 (14.1) | <0.001 |
| eGFR_Scr (mL/min/1.73m2) | 50.5 (13.6) | 43.5 (13.5) | 39.4 (13.7) | 33.2 (13.3) | <0.001 |
| Urine Albumin-to-Creatinine Ratio (μg/mg)*** | 17 (5–117) | 30 (7–316) | 48 (9–447) | 240 (29–1329) | <0.001 |
| Hemoglobin (g/dL) | 13.6 (1.7) | 12.9 (1.6) | 12.6 (1.7) | 12.1 (1.8) | <0.001 |
| Highly Sensitive C-Reactive Protein (mg/L) | 4.7 (9.1) | 4.7 (6.7) | 6.1 (11.9) | 6.1 (10.4) | 0.01 |
Note: Mean (Standard Deviation) reported for continuous variables and percentage for categorical variables. P values are obtained using ANOVA or Kruskal-Wallis tests for continuous variables and Chi-square tests for categorical variables.
High cholesterol defined as total cholesterol ≥240 mg/dL, low-density lipoprotein (LDL) ≥160mg/dL, high-density lipoprotein ≤40 mg/dL, triglycerides ≥200mg/dL or self-reported use of cholesterol-lowering drug.
Reported as Median (Interquartile Range)
Abbreviations: N-terminal pro b-type natriuretic peptide (NT-proBNP); Diet history questionnaire (DHQ); Cystatin C-based estimated glomerular filtration rate (eGFR_CysC); Serum creatinine-based estimated glomerular filtration rate (eGFR_Scr)