Video 1. Prp43 adopts an open conformation after ATP binding and switches into the closed conformation after binding to RNA.

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DOI: 10.7554/eLife.21510.018

This morphing movie between the ADP-bound state of Prp43 (PDBid: 5d0u), the two ADP•BeF₃^- bound states (PDBids: 5ltk and 5ltj) and the ctPrp43ΔN•U₇•ADP•BeF₃^- complex structure (PDBid: 5lta) illustrates the RNA-binding mode of Prp43.

DOI: http://dx.doi.org/10.7554/eLife.21510.018