Table 1.

Summary of known gene deletions and genetic modifications associated with defects in sporozoite egress from oocysts.

DOI: http://dx.doi.org/10.7554/eLife.19157.004

Strain	Egress from oocysts	In vitro motility	Salivary gland invasion	Recognizable domain / function
wt	+++	+++	+++	/
sera5(-)*	-	+++	-	protease
csp-RIImut27	-	n.a.	n.a.	thrombospondin repeat (TSR)
csp(RI−)57	n.a.	+++	++	TSR
csp(RII−)57	n.a.	-	+	TSR
ccp2(-) and ccp3(-)	-	++	n.a.	LCCL-like, ricin, discoidin, ApicA, levanase and neurexin-like domains
pcrmp3(-) and pcrmp4(-)	-	+++	n.a.	CRM domain, EGF-like domain
gama(-)†	-	-	n.a.	/
siap-1(-)	+	-	+	/
orp1(-)‡	-	+++	-	histon-fold domain (HFD)
orp2(-)‡	-	+++	-	HFD
trp1(-)	-	+++	-	TSR

* Previously named ECP1 (Aly and Matuschewski, 2005).

^† Previously named PSOP9 (Ecker et al., 2008).

^‡ Information added during proof (Currà et al., 2016).