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. 2016 Nov 18;2(11):e1600844. doi: 10.1126/sciadv.1600844

Fig. 8. Inhibition of ErbB2 activity with decellularized cardiac ECM treatment.

Fig. 8

To inhibit ErbB2 activity in vivo, the ErbB2 inhibitor AG825 was intraperitoneally injected once (5 mg/kg) immediately after the administration of decellularized cardiac ECM. Cardiac contractile function is indicated by (A) fractional area change and (B) ejection fraction; LV dimension is indicated by (C) EDA and (D) ESA. No significant difference is observed between all groups at all time points (n = 7 per group; all P > 0.05; data analyzed by two-way repeated-measures ANOVA). Dual immunofluorescence detection and quantification of (E and F) c-kit+/Ki67+ proliferating cardiac stem cells and (G and H) ErbB2+/cTnT+ cardiomyocytes. No significant difference is observed between all groups (n = 4 per group, all P > 0.05). Scale bars, 50 μm.