TABLE 2.
Clinical characteristics and demographics for all patients with completely excised high-grade soft tissue sarcomas of the extremity (N = 1318)
| Feature | No. | % | Median | IQR |
|---|---|---|---|---|
| Age (years) | 54 | 38, 58 | ||
| Sex | ||||
| Male | 728 | 55.2 | ||
| Female | 590 | 44.8 | ||
| Tumor size category | ||||
| ≤5 cm | 468 | 35.5 | ||
| 5–10 cm | 428 | 32.5 | ||
| >10 cm | 416 | 31.6 | ||
| Unknown | 6 | 0.5 | ||
| Depth | ||||
| Superficial | 265 | 20.1 | ||
| Deep | 1053 | 79.9 | ||
| Site | ||||
| Upper extremity | 354 | 26.9 | ||
| Lower extremity | 964 | 73.1 | ||
| Subsite | ||||
| Hand | 37 | 2.8 | ||
| Forearm | 99 | 7.5 | ||
| Elbow | 26 | 2.0 | ||
| Arm | 91 | 6.9 | ||
| Axilla | 33 | 2.5 | ||
| Shoulder | 68 | 5.2 | ||
| Groin | 43 | 3.3 | ||
| Hip | 12 | 0.9 | ||
| Thigh | 607 | 46.0 | ||
| Knee | 73 | 5.5 | ||
| Leg | 149 | 11.3 | ||
| Ankle | 22 | 1.7 | ||
| Foot | 58 | 4.4 | ||
| Histology, variant | ||||
| MFH/HGPS | 522 | 39.6 | ||
| Pleomorphic | 200 | 38.3 | ||
| Myxofibrosarcomatous | 171 | 32.8 | ||
| Giant Cell | 10 | 1.9 | ||
| Inflammatory | 2 | 0.4 | ||
| NOS | 139 | 26.6 | ||
| Synovial sarcoma | 208 | 15.8 | ||
| Monophasic | 136 | 65.4 | ||
| Biphasic | 70 | 33.7 | ||
| NOS | 2 | 0.9 | ||
| Liposarcoma | 168 | 12.7 | ||
| Myxoid/round cell | 83 | 49.4 | ||
| Pleomorphic | 57 | 33.9 | ||
| Dedifferentiated | 21 | 12.5 | ||
| NOS | 7 | 4.2 | ||
| Leiomyosarcoma | 142 | 10.8 | ||
| MPNST | 51 | 3.9 | ||
| Fibrosarcoma | 34 | 2.6 | ||
| Other | 193 | 14.6 | ||
| Presentation Status | ||||
| No prior treatment | 260 | 19.7 | ||
| Biopsy only | 555 | 42.1 | ||
| Marginal excision | 371 | 28.1 | ||
| Wide excision | 132 | 10.0 | ||
| Radiation-induced | ||||
| Yes | 19 | 1.4 | ||
| No | 1299 | 98.6 | ||
| Zip code upon referral | ||||
| First 3 digits | 112 | 087, 125 | ||
| Surgeon | ||||
| A | 318 | 24.2 | ||
| B | 245 | 18.6 | ||
| C | 146 | 11.1 | ||
| D | 123 | 9.3 | ||
| E | 116 | 8.8 | ||
| F | 103 | 7.8 | ||
| G | 102 | 7.8 | ||
| Other | 165 | 12.4 | ||
| Surgical Service | ||||
| GMT | 798 | 60.6 | ||
| Orthopaedic Surgery | 512 | 38.8 | ||
| Other | 8 | 0.6 | ||
| Tumor bed excision | ||||
| Yes | 457 | 34.7 | ||
| No | 498 | 37.8 | ||
| Missing | 363 | 27.5 | ||
| Procedure | ||||
| Amputation | 106 | 8.0 | ||
| Limb-sparing surgery | 1212 | 92.0 | ||
| Bone invasion | ||||
| Yes | 51 | 3.9 | ||
| No | 1196 | 90.7 | ||
| Missing | 71 | 5.4 | ||
| Bone resected | ||||
| Yes | 183 | 13.9 | ||
| No | 1031 | 78.2 | ||
| Missing | 104 | 7.9 | ||
| Nerve invasion | ||||
| Yes | 27 | 2.1 | ||
| No | 1137 | 86.3 | ||
| Missing | 154 | 11.6 | ||
| Nerve resected | ||||
| Yes | 156 | 11.8 | ||
| No | 1001 | 78.0 | ||
| Missing | 161 | 12.2 | ||
| Vascular invasion | ||||
| Yes | 73 | 5.5 | ||
| No | 1081 | 82.0 | ||
| Missing | 164 | 12.4 | ||
| Chemotherapy | ||||
| Preop | 164 | 12.4 | ||
| Postop | 202 | 15.3 | ||
| None | 952 | 72.2 | ||
| Radiotherapy | ||||
| Preop | 51 | 3.9 | ||
| Postop | 579 | 43.9 | ||
| None | 688 | 52.2 | ||
| LR | 194 | 14.7 | ||
| Time to LR (months) | 15 | 6, 29.5 | ||
| DR | 419 | 31.8 | ||
| Time to DR (months) | 11 | 5, 24 | ||
| Death from disease | 349 | 26.5 | ||
| Follow-up time (months) | 39 | 14.6, 96.8 |
IQR = interquartile range; MFH/HGPS = malignant fibrous histiocytoma/high-grade pleomorphic sarcoma; NOS = not otherwise specified; MPNST = malignant peripheral nerve sheath tumor; GMT = Gastric & Mixed Tumor; LR = local recurrence; DR = distant recurrence.