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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Neurooncol. 2016 Sep 19;131(1):125–133. doi: 10.1007/s11060-016-2278-7

Fig. 3.

Fig. 3

Meta-analyses of published multivariate HRs comparing overall (a) and progression free (c) survival in LV+GBM and LV−GBM patients. b, d Funnel plots demonstrating publication bias for a and c meta-analyses, respectively. Lines represent 95 % confidence interval obtained after trim and fill analysis. Each open circle represents a study included in the meta-analysis. Closed, dark circles represent non-existent studies compensating for publication bias with the trim and fill method and resulting summary HR and confidence interval is represented as a closed, dark diamond. These analyses were not performed in d