Table 3.
Estimated crude and adjusted hazard ratios for incidence of ESRF in all patients. *full model includes all variables, since analyses were conducted on the age-scale, effects are taking account of current age; **interaction parameters (95%CI): crude model: -0.088 (-0.162,-0.014); p = 0.019 full model: -0.093 (-0.174,-0.012); p = 0.024; #effect of 100 mg/mmol creatinine = (displayed hazard ratio)0.7 effect of 200 mg/mmol creatinine = (displayed hazard ratio)1.4; ##effect of 10 ml/min/1.73 m2 decrease = (displayed hazard ratio)2 effect of 15 ml/min/1.73 m2 decrease = (displayed hazard ratio)3
| Hazard ratios | |||||||
| Estimated effects of | categories/unit | crude | 95%CI | p-value | Adjusted* | 95%CI | p-value |
| Gender | female | 1.00 | 1.00 | ||||
| male | 1.17 | (0.55, 2.50) | 0.677 | 0.55 | (0.21,1.39) | 0.205 | |
| Type of reflux | primary | 1.00 | 1.00 | ||||
| secondary | 1.28 | (0.65, 2.55) | 0.478 | 1.73 | (0.73, 4.06) | 0.211 | |
| Proteinuria | per 50 mg/mmol proteinuria increase# | 1.71 | (1.33, 2.20) | <0.001 | 1.50 | (1.17, 1.91) | 0.001 |
| eGFR** | per 5 ml/min/1.73 m2 decrease## | 1.38 | (1.16, 1.64) | <0.001 | 1.29 | (1.05, 1.58) | 0.016 |
| ACE inhibitor** | at 30 ml/min/1.73 m2 | 0.53 | (0.22, 1.29) | 0.162 | 0.67 | (0.27, 1.67) | 0.393 |
| at 35 ml/min/1.73 m2 | 0.34 | (0.12, 1.00) | 0.051 | 0.42 | (0.14, 1.26) | 0.121 | |
| at 40 ml/min/1.73 m2 | 0.22 | (0.06, 0.84) | 0.027 | 0.27 | (0.07, 1.04) | 0.058 | |
| at 45 ml/min/1.73 m2 | 0.14 | (0.03, 0.73) | 0.02 | 0.17 | (0.03, 0.91) | 0.039 | |