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Anti-CRM197 antibody response in mice immunized with CRM197. (A) Specific anti-CRM197 Ig titers and (B) Ig isotype concentration (IgG1, IgG2b, IgG2c, IgG3, IgA and IgM) quantified by ELISA in sera obtained from C57BL/6J mice immunized (CRM197) or not (saline) with CRM197. Sera were collected 30 d after prime injection. Data are mean ± standard error of the mean from six mice per group; each dot represents an individual mouse serum.
