Table 1.
Splenectomy and stroke outcome in rodents.
| strain | stroke model | timing of splenectomy (relative to stroke) | survival | outcome (method of infarct analysis) | behavior | reference |
|---|---|---|---|---|---|---|
| mice | ||||||
| C57BL/6 | 30 min MCAO | immediately before | 3 d | • no change in infarct size (phase contrast microscopy) | • none | 10 |
| 7 d | ||||||
| C57BL/6 | 60 min MCAO | 2 wks before | 4 d | • ↓′d infarct size in males (TTC) | • none | 9 |
| rats | ||||||
| Lewis | 120 min MCAO | immediately before | 3 d | • no change in infarct size (TTC) • worse neurological scores early after MCAO |
• yes | current study |
| 4 wks | • no change in behavioral outcome | |||||
| Sprague-Dawley | 90 min MCAO | immediately after reperfusion | 7 d | • ↓′d infarct size (MRI) • no difference in neurological scores |
• limited | 7 |
| Sprague-Dawley | permanent focal ischemia | 2 wks before | 24 hrs | • ↓′d infarct size (Nissl) | • none | 5 |
| Sprague-Dawley | permanent focal ischemia | 2 wks before | 4 d | • ↓′d infarct size (fluorojade) | • none | 6 |
| Sprague-Dawley | permanent focal ischemia | 2 wks before | 4 d | • ↓′d infarct size (fluorojade) | • none | 4 |
| Sprague-Dawley | HI injury | 3 days prior | 3 hrs | • no change in infarct size (TTC) | • yes | 8 |
| 3 d | • ↓′d infarct size (TTC) | |||||
| 3 wks | • improved behavioral outcome | |||||
ns=not specified, MCAO=middle cerebral artery occlusion, TTC=2,3,5-triphenyl-2H-tetrazolium chloride, HI=hypoxia/ischemia