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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Immunol. 2016 Dec 28;198(3):1142–1155. doi: 10.4049/jimmunol.1601297

FIGURE 7.

FIGURE 7

ThCTL express effector genes and suppress circulation and memory genes compared to non-ThCTL. (A) Naïve HNT.Thy1.1 CD4 T cells were adoptively transferred into BALB/cByJ mice that were then infected with A/PR8. Left: Microarray heat map showing gene expression profiles of NKG2A/C/E+ or NKG2A/C/Eneg HNT.Thy1.1 CD4 T cells sorted from pooled lungs at 7 dpi. Right: Additional genes associated with cytotoxicity and T helper differentiation. Microarray ran twice with n=10 mice each time, indicated as 1 & 2. (B) Naïve OT-II.Thy1.1 CD4 T cells were adoptively transferred into B6 mice that were then infected with A/PR8-OVAII. Fold change in expression of indicated genes from quantitative real time PCR expressed by NKG2A/C/E+ over NKG2A/C/Eneg CD4 T cells 8 dpi. Data shown is pooled from 3 independent experiments, with RNA from NKG2A/C/E+ or NKG2A/C/Eneg OT-II CD4 T cells sorted from pooled lungs, n=10 mice each experiment.