Figure 3.

Geniposide treatment attenuates the oligomeric Aβ-induced increase in neuritic ROS. (A) Representative images of DCF staining of hippocampal neurites treated with vehicle, oligomeric Aβ_1–42 (200 nM), or oligomeric Aβ_1–42+geniposide (10 μM). Scale bar = 10 μm. (B) Quantification of DCF intensity in (A). The intensity of DCF-labeled neurites was significantly increased in neurons treated with oligomeric Aβ_1–42 for 24 h, while the geniposide treatment dramatically reduced the Aβ-induced ROS elevation. ^**p < 0.01 vs. vehicle-treated group, ^##p < 0.01 vs. Aβ-treated group. n = 4 independent cultures.