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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Transplantation. 2017 Feb;101(2):322–331. doi: 10.1097/TP.0000000000001552

Table 1.

IC50 values for inhibition of kinase activity by BTKB66

Kinase IC50, nM
Btk 13.3

TEC 195

BLK 325

FGR 469

PTK6 (Brk) 493

ABL1 FRK (PTK5) PAK1 >1000
ACVR1B (ALK4) FYN PAK2 (PAK65)
ADCK3 GSK3B PAK4
AKT1 (PKB alpha) HCK PDGFRA
AKT2 (PKB beta) IGF1R PDGFRB
ALK IKBKB PDK1 Direct
AURKA (Aurora A) INSR PIK3C2B
AURKB (Aurora B) ITK PIK3CA/PIK3R1
AXL JAK1 PIK3CG
BMPR2 JAK2 PIM1
BRAF JAK3 PIM2
CDK11 KDR (VEGFR2) PIM3
CDK16 KIT PLK1
CDK2/cyclin A LCK PRKACA (PKA)
CDK3/cyclin E1 LYN A PRKCE
CDK7/cyclin H MAP2K1 (MEK1) PTK2 (FAK)
CDK9/cyclin T1 MAP2K2 (MEK2) RAF1 (cRAF)
CHEK1 (CHK1) MAP3K9 (MLK1) RET
CHUK (IKK alpha) MAPK10 (JNK3) RIPK2
CSF1R (FMS) MAPK14 (p38 alpha) ROCK2
CSK MAPK3 (ERK1) RPS6KA1 (RSK1)
CSNK1D MAPK8 (JNK1) SRC
CSNK1G2 MAPK9 (JNK2) STK22D (TSSK1)
DCAMKL1 MAPKAPK2 STK32C (YANK3)
DYRK1B MARK3 SYK
EGFR (ErbB1) MET (cMet) TEK (Tie2)
EPHA2 MKNK1 TGFBR1 (ALK5)
ERBB2 (HER2) MKNK2 TYK2
FER NEK2 ULK2
FGFR2 NTRK1 (TRKA) YES1
FGFR3 NUAK2 ZAP70
FLT3