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. 2017 Jan 25;8:3. doi: 10.3389/fphar.2017.00003

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Copyright © 2017 López-Riera, Conde, Tolosa, Zaragoza, Castell, Gómez-Lechón and Jover.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap clustering analysis of expression patterns of 35 miRNAs reveals that steatotic drugs have a common fingerprint. HepG2 cells were treated with model steatotic (VALP, DOXY, CYCA, AMIO, and TAMO) and non-steatotic (DMSO, KETO, AMIT, and CITR) compounds for 24 h. Two different non-cytotoxic concentrations (labeled H and L) were used. FA 0.6 mM (2:1 oleate:palmitate). Intracellular miRNA levels were analyzed by qRT-PCR-TaqMan assays in 3–5 independent experiments and normalized with the mean of miR-let7a and miR-25. Heatmap and clustering was carried out with MeV: MultiExperiment Viewer. Red asterisk denotes miRNAs upregulated by most steatotic drugs.