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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Stroke. 2017 Jan 5;48(2):445–451. doi: 10.1161/STROKEAHA.116.014790

Figure 1.

Figure 1

A, Increasing amounts of warfarin added to the drinking water of mice led to increased INR values 24 hours later (**p<0.01, ***p<0.001 compared to no added warfarin; n=6/group). B, Experimental setup with 24 h warfarin pre-administration, followed by either 3h of MCAO (setup A) or 2h of MCAO, followed by tPA treatment 1h after reperfusion (setup B). Timeline not to scale. C, Photometrically determined hemoglobin levels in the ipsilateral brain hemisphere following warfarin pretreatment and 3h of MCAO were significantly lower in 12/15-LOX ko mice compared to matching wild type mice (*p<0.05; n=5/group).